Potential Effects of Nutraceuticals in Retinopathy of Prematurity

Retinopathy of prematurity (ROP), the most common cause childhood blindness, is a hypoxia-induced eye disease characterized by retinal neovascularization. In normal retina, well-organized vascular network provides oxygen and nutrients as energy sources to maintain visual function; however, it disrupted when pathological angiogenesis induced in ROP patients. Under hypoxia, inadequate supply lead oxidative stress stimulate neovasculature formation well affecting function photoreceptors. order meet metabolic needs developing protection against abnormal one way manage ROP. Although current treatments provide beneficial effects reducing severity ROP, these invasive therapies may also induce life-long consequences such systemic structural functional complications neurodevelopment disruption infants. Nutritional supplements for newborns are novel concept restoring protecting vasculature better management. Nutraceuticals provided non-invasive manner without developmental side associated with treatments. These nutraceuticals have been investigated through various vitro vivo methods indicated protect vasculature. Here, we reviewed discussed how use be prevention